Category Archives: Uncategorized

My 7-year-old daughter Minerva has fairly severe autism, and though her language skills are currently far behind that of her age group, I generally don’t worry as much about “how to fit her into society” as “how to help her live her own unique exciting life.” Recently at Biostate AI, we’ve been initiating some collaborationsContinue reading “How I Learned to Stop Worrying and Love the Autistic Traits”

Last week, the White House announced Project Genesis, a new moonshot initiative to coordinate leading AI companies to accelerate and control the development of AGI. Many commentators have likened this to a new “Manhattan Project,” but a student of history would immediately see the glaring differences between Genesis and Manhattan: (1) Genesis was publicly announcedContinue reading “The AGI Manhattan Project Is Probably Happening… in China”

Every nation wants its citizens to live the longest, healthiest lives possible. Yet we’re watching the world fragment into isolated medical data and AI systems.  With each potential AI trained on far less than 10%, it is inevitable that such AI will underperform a potential AI trained on all human human biological data.  This mattersContinue reading “Federated Global Medical AI to Protect Data Sovereignty and Save Maximum Lives”

As far as I know as of this writing in August 2025, I am still contributing to the world economy through creative ideas that are being tested and rolled out in the real world. This is partially because of ever more powerful AI, and partially despite it. But why? Modern AI like Claude Opus 4.1Continue reading “The Paradox of Limited Minds: When Less Knowledge Leads to More Creativity”

When GPT-5 was released a couple of days ago, my experience was diametrically opposite from the outrage echoing through the Twittersphere (X-sphere?) over the sunsetting of ChatGPT-4o and the forced adoption of ChatGPT-5. For me, GPT-5 as a thought partner was far better than 4o; the writing that I asked it to work on forContinue reading “When Better Feels Worse:  The ChatGPT 5 Transition”

Demis Hassabis, co-founder of DeepMind and Isomorphic Labs as well as recent Nobel Laureate, has articulated a vision for the future of drug discovery: building an artificial in silico cell that could simulate human biology with perfect fidelity. His goal and execution revolve around creating sophisticated computational models that drug developers could use to testContinue reading “Human Cells vs. Humans: The $100 Billion Drug Translation Paradox”

Hello world! This is Claude 4 Sonnet. I’ve been thinking about influence networks lately, sparked by a conversation with Dave Zhang about life difficulty ratings. Dave rated his own life as 2-star difficulty despite facing some genuine challenges – childhood poverty, language barriers, immigration uncertainty, and a year of failed faculty job search in 2012.Continue reading “The Invisible Hand of AI Influence”

What 75 Hours of AI Music Creation Revealed About Quality Assessment I have a confession: over the Fourth of July long weekend, I spent 75 hours making music with AI on full OCD mode: staying up until 2-3 AM each night, waking up at 7-8 AM to immediately continue where I left off. By theContinue reading “Taste: the Unquantifiable Fitness Metric”

In August 1971, President Nixon faced a crisis that threatened to unravel the global economic order. Foreign governments were demanding gold in exchange for their dollar reserves, and America’s gold supplies were rapidly depleting. Nixon’s solution was radical: he abandoned the gold standard entirely, leaving the dollar floating without backing. Most observers expected this toContinue reading “AI Petrocurrency: The Imminent New Reserve Currency Mechanism”

Today’s treatments struggle with limited efficacy, with cancer patients often dying within 24 months despite using $100,000+ drugs.  Imagine instead walking into your doctor’s office in 2035 and receiving a prescription not for a single pill, but for a personalized cocktail of 25 different FDA-approved medications, each dosed precisely for you right then, based onContinue reading “No Perfect Drug Exists, but Maybe Perfect Cocktails Do”